Sujet de stage de Master Détection de rupture multivariée et classfication de courbes pour l'analyse de cinétique de métabolites

This internship is part of the HepatoTwin research project (2024–2028), coordinated by INRAE and conducted in collaboration with the TOXALIM research unit, a leading laboratory in food toxicology. The HepatoTwin project aims to investigate the impact of food contaminants and dietary imbalances on liver metabolism using advanced experimental and computational approaches. Within this project, high-frequency multivariate time series data are collected from human hepatic cell cultures, monitoring the real-time dynamics of dozens to hundreds of metabolites. Cells are exposed to different stress conditions mimicking food contaminant exposure or unbalanced diets, potentially inducing either abrupt metabolic disruptions or more gradual changes in metabolic dynamics.